RT Journal
A1 Raymond, Christopher K.
A1 Kas, Arnold
A1 Paddock, Marcia
A1 Qiu, Ruolan
A1 Zhou, Yang
A1 Subramanian, Sandhya
A1 Chang, Jean
A1 Palmieri, Anthony
A1 Haugen, Eric
A1 Kaul, Rajinder
A1 Olson, Maynard V.
T1 Ancient haplotypes of the HLA Class II region
JF Genome Research 
JO Genome Research 
YR 2005 
FD September 01 
VO 15 
IS 9 
SP 1250 
OP 1257 
DO 10.1101/gr.3554305 
UL http://genome.cshlp.org/content/15/9/1250.abstract 
AB Allelic variation in codons that specify amino acids that line the peptide-binding pockets of HLA's Class II antigen-presenting proteins is superimposed on strikingly few deeply diverged haplotypes. These haplotypes appear to have been evolving almost independently for tens of millions of years. By complete resequencing of 20 haplotypes across the ∼100-kbp region that spans the HLA-DQA1, -DQB1, and -DRB1 genes, we provide a detailed view of the way in which the genome structure at this locus has been shaped by the interplay of selection, gene-gene interaction, and recombination.