TY  - JOUR
A1  - Raymond, Christopher K.
A1  - Kas, Arnold
A1  - Paddock, Marcia
A1  - Qiu, Ruolan
A1  - Zhou, Yang
A1  - Subramanian, Sandhya
A1  - Chang, Jean
A1  - Palmieri, Anthony
A1  - Haugen, Eric
A1  - Kaul, Rajinder
A1  - Olson, Maynard V.
T1  - Ancient haplotypes of the HLA Class II region
Y1  - 2005/09/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1250 
EP  - 1257 
DO  - 10.1101/gr.3554305 
VL  - 15 
IS  - 9 
UR  - http://genome.cshlp.org/content/15/9/1250.abstract 
N2  - Allelic variation in codons that specify amino acids that line the peptide-binding pockets of HLA's Class II antigen-presenting proteins is superimposed on strikingly few deeply diverged haplotypes. These haplotypes appear to have been evolving almost independently for tens of millions of years. By complete resequencing of 20 haplotypes across the ∼100-kbp region that spans the HLA-DQA1, -DQB1, and -DRB1 genes, we provide a detailed view of the way in which the genome structure at this locus has been shaped by the interplay of selection, gene-gene interaction, and recombination. 
ER  -