@article{Liu01032005,
author = {Liu, Xiao and Noll, David M. and Lieb, Jason D. and Clarke, Neil D.}, 
title = {DIP-chip: Rapid and accurate determination of DNA-binding specificity},
volume = {15}, 
number = {3}, 
pages = {421-427}, 
year = {2005}, 
doi = {10.1101/gr.3256505}, 
abstract ={We have developed a new method for determining the DNA-binding specificity of proteins. In DIP-chip (DNA immunoprecipitation with microarray detection), protein·DNA complexes are isolated from an in vitro mixture of purified protein and naked genomic DNA. Whole-genome DNA microarrays are used to identify the protein-bound DNA fragments, and the sequence of the identified fragments is used to derive binding-site descriptions. Using objective criteria for assessing the accuracy of DNA-binding motifs, and using yeast Leu3p as a model, we demonstrate that motifs determined by DIP-chip are as effective at predicting the location of bound proteins in vivo as are motifs determined by conventional low-throughput in vitro methods.}, 
URL = {http://genome.cshlp.org/content/15/3/421.abstract}, 
eprint = {http://genome.cshlp.org/content/15/3/421.full.pdf+html}, 
journal = {Genome Research} 
}