TY  - JOUR
A1  - Kukita, Yoji
A1  - Miyatake, Katsuyuki
A1  - Stokowski, Renee
A1  - Hinds, David
A1  - Higasa, Koichiro
A1  - Wake, Norio
A1  - Hirakawa, Toshio
A1  - Kato, Hidenori
A1  - Matsuda, Takao
A1  - Pant, Krishna
A1  - Cox, David
A1  - Tahira, Tomoko
A1  - Hayashi, Kenshi
T1  - Genome-wide definitive haplotypes determined using a collection of complete hydatidiform moles
Y1  - 2005/11/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1511 
EP  - 1518 
DO  - 10.1101/gr.4371105 
VL  - 15 
IS  - 11 
UR  - http://genome.cshlp.org/content/15/11/1511.abstract 
N2  - We present genome-wide definitive haplotypes, determined using a collection of 74 Japanese complete hydatidiform moles, each carrying a genome derived from a single sperm. The haplotypes incorporate 281,439 common SNPs, genotyped with a high throughput array-based oligonucleotide hybridization technique. Comparison of haplotypes inferred from pseudoindividuals (constructed from randomized mole pairs) with those of moles showed some switch errors in resolution of phases by the computational inference method. The effects of these errors on local haplotype structure and selection of tag SNPs are discussed. We also show that definitive haplotypes of moles may be useful for elucidation of long-range haplotype structure, and should be more effective for detecting extended haplotype homozygosity indicative of positive selection. 
ER  -