TY  - JOUR
A1  - Petkov, Petko M.
A1  - Ding, Yueming
A1  - Cassell, Megan A.
A1  - Zhang, Weidong
A1  - Wagner, Gunjan
A1  - Sargent, Evelyn E.
A1  - Asquith, Steven
A1  - Crew, Victor
A1  - Johnson, Kevin A.
A1  - Robinson, Phil
A1  - Scott, Valerie E.
A1  - Wiles, Michael V.
T1  - An Efficient SNP System for Mouse Genome Scanning and Elucidating Strain Relationships
Y1  - 2004/09/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1806 
EP  - 1811 
DO  - 10.1101/gr.2825804 
VL  - 14 
IS  - 9 
UR  - http://genome.cshlp.org/content/14/9/1806.abstract 
N2  - A set of 1638 informative SNP markers easily assayed by the Amplifluor genotyping system were tested in 102 mouse strains, including the majority of the common and wild-derived inbred strains available from The Jackson Laboratory. Selected from publicly available databases, the markers are on average ∼1.5 Mb apart and, whenever possible, represent the rare allele in at least two strains. Amplifluor assays were developed for each marker and performed on two independent DNA samples from each strain. The mean number of polymorphisms between strains was 608±136 SD. Several tests indicate that the markers provide an effective system for performing genome scans and quantitative trait loci analyses in all but the most closely related strains. Additionally, the markers revealed several subtle differences between closely related mouse strains, including the groups of several 129, BALB, C3H, C57, and DBA strains, and a group of wild-derived inbred strains representing several Mus musculus subspecies. Applying a neighbor-joining method to the data, we constructed a mouse strain family tree, which in most cases confirmed existing genealogies. 
ER  -