TY - JOUR A1 - Pevzner, Paul A. A1 - Tang, Haixu A1 - Tesler, Glenn T1 - De Novo Repeat Classification and Fragment Assembly Y1 - 2004/09/01 JF - Genome Research JO - Genome Research SP - 1786 EP - 1796 DO - 10.1101/gr.2395204 VL - 14 IS - 9 UR - http://genome.cshlp.org/content/14/9/1786.abstract N2 - Repetitive sequences make up a significant fraction of almost any genome, and an important and still open question in bioinformatics is how to represent all repeats in DNA sequences. We propose a new approach to repeat classification that represents all repeats in a genome as a mosaic of sub-repeats. Our key algorithmic idea also leads to new approaches to multiple alignment and fragment assembly. In particular, we show that our FragmentGluer assembler improves on Phrap and ARACHNE in assembly of BACs and bacterial genomes. ER -