@article{Asthana01062004, author = {Asthana, Saurabh and King, Oliver D. and Gibbons, Francis D. and Roth, Frederick P.}, title = {Predicting Protein Complex Membership Using Probabilistic Network Reliability}, volume = {14}, number = {6}, pages = {1170-1175}, year = {2004}, doi = {10.1101/gr.2203804}, abstract ={Evidence for specific protein–protein interactions is increasingly available from both small- and large-scale studies, and can be viewed as a network. It has previously been noted that errors are frequent among large-scale studies, and that error frequency depends on the large-scale method used. Despite knowledge of the error-prone nature of interaction evidence, edges (connections) in this network are typically viewed as either present or absent. However, use of a probabilistic network that considers quantity and quality of supporting evidence should improve inference derived from protein networks. Here we demonstrate inference of membership in a partially known protein complex by using a probabilistic network model and an algorithm previously used to evaluate reliability in communication networks.}, URL = {http://genome.cshlp.org/content/14/6/1170.abstract}, eprint = {http://genome.cshlp.org/content/14/6/1170.full.pdf+html}, journal = {Genome Research} }