TY  - JOUR
A1  - Seldin, Michael F.
A1  - Morii, Takanobu
A1  - Collins-Schramm, Heather E.
A1  - Chima, Bill
A1  - Kittles, Rick
A1  - Criswell, Lindsey A.
A1  - Li, Hongzhe
T1  - Putative Ancestral Origins of Chromosomal Segments in Individual African Americans: Implications for Admixture Mapping
Y1  - 2004/06/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1076 
EP  - 1084 
DO  - 10.1101/gr.2165904 
VL  - 14 
IS  - 6 
UR  - http://genome.cshlp.org/content/14/6/1076.abstract 
N2  - Theoretically, markers that distinguish European from West African ancestry can be used to examine the origin of chromosomal segments in individual African Americans. In this study, putative ancestral origin was examined by using haplotypes estimated from genotyping 268 African Americans for 29 ancestry informative markers spaced over a 60-cM segment of chromosome 5. Analyses using a Bayesian algorithm (STRUCTURE) provided evidence that blocks of individual chromosomes derive from one or the other parental population. In addition, modeling studies were performed by using hidden real marker data to simulate patient and control populations under different genotypic risk ratios. Ancestry analysis showed significant results for a genotypic risk ratio of 2.5 in the African American population for modeled susceptibility genes derived from either putative parental population. These studies suggest that admixture mapping in the African American population can provide a powerful approach to defining genetic factors for some disease phenotypes. 
ER  -