TY  - JOUR
A1  - Birney, Ewan
A1  - Clamp, Michele
A1  - Durbin, Richard
T1  - GeneWise and Genomewise
Y1  - 2004/05/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 988 
EP  - 995 
DO  - 10.1101/gr.1865504 
VL  - 14 
IS  - 5 
UR  - http://genome.cshlp.org/content/14/5/988.abstract 
N2  - We present two algorithms in this paper: GeneWise, which predicts gene structure using similar protein sequences, and Genomewise, which provides a gene structure final parse across cDNA- and EST-defined spliced structure. Both algorithms are heavily used by the Ensembl annotation system. The GeneWise algorithm was developed from a principled combination of hidden Markov models (HMMs). Both algorithms are highly accurate and can provide both accurate and complete gene structures when used with the correct evidence. 
ER  -