@article{Birney01052004,
author = {Birney, Ewan and Clamp, Michele and Durbin, Richard}, 
title = {GeneWise and Genomewise},
volume = {14}, 
number = {5}, 
pages = {988-995}, 
year = {2004}, 
doi = {10.1101/gr.1865504}, 
abstract ={We present two algorithms in this paper: GeneWise, which predicts gene structure using similar protein sequences, and Genomewise, which provides a gene structure final parse across cDNA- and EST-defined spliced structure. Both algorithms are heavily used by the Ensembl annotation system. The GeneWise algorithm was developed from a principled combination of hidden Markov models (HMMs). Both algorithms are highly accurate and can provide both accurate and complete gene structures when used with the correct evidence.}, 
URL = {http://genome.cshlp.org/content/14/5/988.abstract}, 
eprint = {http://genome.cshlp.org/content/14/5/988.full.pdf+html}, 
journal = {Genome Research} 
}