RT Journal
A1 Eyras, Eduardo
A1 Caccamo, Mario
A1 Curwen, Val
A1 Clamp, Michele
T1 ESTGenes: Alternative Splicing From ESTs in Ensembl
JF Genome Research 
JO Genome Research 
YR 2004 
FD May 01 
VO 14 
IS 5 
SP 976 
OP 987 
DO 10.1101/gr.1862204 
UL http://genome.cshlp.org/content/14/5/976.abstract 
AB We describe a novel algorithm for deriving the minimal set of nonredundant transcripts compatible with the splicing structure of a set of ESTs mapped on a genome. Sets of ESTs with compatible splicing are represented by a special type of graph. We describe the algorithms for building the graphs and for deriving the minimal set of transcripts from the graphs that are compatible with the evidence. These algorithms are part of the Ensembl automatic gene annotation system, and its results, using ESTs, are provided at www.ensembl.org as ESTgenes for the mosquito, Caenorhabditis briggsae, C. elegans, zebrafish, human, mouse, and rat genomes. Here we also report on the results of this method applied to the human and mouse genomes.