RT Journal A1 Stalker, James A1 Gibbins, Brian A1 Meidl, Patrick A1 Smith, James A1 Spooner, William A1 Hotz, Hans-Rudolf A1 Cox, Antony V. T1 The Ensembl Web Site: Mechanics of a Genome Browser JF Genome Research JO Genome Research YR 2004 FD May 01 VO 14 IS 5 SP 951 OP 955 DO 10.1101/gr.1863004 UL http://genome.cshlp.org/content/14/5/951.abstract AB The Ensembl Web site (http://www.ensembl.org/) is the principal user interface to the data of the Ensembl project, and currently serves >500,000 pages (∼2.5 million hits) per week, providing access to >80 GB (gigabyte) of data to users in more than 80 countries. Built atop an open-source platform comprising Apache/mod_perl and the MySQL relational database management system, it is modular, extensible, and freely available. It is being actively reused and extended in several different projects, and has been downloaded and installed in companies and academic institutions worldwide. Here, we describe some of the technical features of the site, with particular reference to its dynamic configuration that enables it to handle disparate data from multiple species.