TY  - JOUR
A1  - Curwen, Val
A1  - Eyras, Eduardo
A1  - Andrews, T. Daniel
A1  - Clarke, Laura
A1  - Mongin, Emmanuel
A1  - Searle, Steven M.J.
A1  - Clamp, Michele
T1  - The Ensembl Automatic Gene Annotation System
Y1  - 2004/05/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 942 
EP  - 950 
DO  - 10.1101/gr.1858004 
VL  - 14 
IS  - 5 
UR  - http://genome.cshlp.org/content/14/5/942.abstract 
N2  - As more genomes are sequenced, there is an increasing need for automated first-pass annotation which allows timely access to important genomic information. The Ensembl gene-building system enables fast automated annotation of eukaryotic genomes. It annotates genes based on evidence derived from known protein, cDNA, and EST sequences. The gene-building system rests on top of the core Ensembl (MySQL) database schema and Perl Application Programming Interface (API), and the data generated are accessible through the Ensembl genome browser (http://www.ensembl.org). To date, the Ensembl predicted gene sets are available for the A. gambiae, C. briggsae, zebrafish, mouse, rat, and human genomes and have been heavily relied upon in the publication of the human, mouse, rat, and A. gambiae genome sequence analysis. Here we describe in detail the gene-building system and the algorithms involved. All code and data are freely available from http://www.ensembl.org. 
ER  -