TY  - JOUR
A1  - Twigger, Simon N.
A1  - Nie, Jeff
A1  - Ruotti, Victor
A1  - Yu, Jiaming
A1  - Chen, Dan
A1  - Li, Dawei
A1  - Mathis, Jed
A1  - Narayanasamy, Vijay
A1  - Gopinath, Gopal R.
A1  - Pasko, Dean
A1  - Shimoyama, Mary
A1  - de la Cruz, Norberto
A1  - Bromberg, Susan
A1  - Kwitek, Anne E.
A1  - Jacob, Howard J.
A1  - Tonellato, Peter J.
T1  - Integrative Genomics: In Silico Coupling of Rat Physiology and Complex Traits With Mouse and Human Data
Y1  - 2004/04/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 651 
EP  - 660 
DO  - 10.1101/gr.1974504 
VL  - 14 
IS  - 4 
UR  - http://genome.cshlp.org/content/14/4/651.abstract 
N2  - Integration of the large variety of genome maps from several organisms provides the mechanism by which physiological knowledge obtained in model systems such as the rat can be projected onto the human genome to further the research on human disease. The release of the rat genome sequence provides new information for studies using the rat model and is a key reference against which existing and new rat physiological results can be aligned. Previously, we described comparative maps of the rat, mouse, and human based on EST sequence comparisons combined with radiation hybrid maps. Here, we use new data and introduce the Integrated Genomics Environment, an extensive database of curated and integrated maps, markers, and physiological results. These results are integrated by using VCMapview, a java-based map integration and visualization tool. This unique environment allows researchers to relate results from cytogenetic, genetic, and radiation hybrid studies to the genome sequence and compare regions of interest between human, mouse, and rat. Integrating rat physiology with mouse genetics and clinical results from human by using the respective genomes provides a novel route to capitalize on comparative genomics and the strengths of model organism biology. 
ER  -