TY  - JOUR
A1  - Cao, Dachuang
A1  - Osborn, Thomas C.
A1  - Doerge, Rebecca W.
T1  - Correct Estimation of Preferential Chromosome Pairing in Autotetraploids
Y1  - 2004/03/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 459 
EP  - 462 
DO  - 10.1101/gr.1596604 
VL  - 14 
IS  - 3 
UR  - http://genome.cshlp.org/content/14/3/459.abstract 
N2  - In recent work, a statistical model was proposed for the purpose of estimating parameters associated with quantitative trait locus (QTL) mapping and preferential pairing within a polyploidy framework. The statistical model contained several parameters that, when estimated from experimental data, supplied information about QTL, including a preferential pairing factor. Among the results reported were estimates of preferential pairing, many of which indicated high levels of preferential pairing (p = 0.60) that were inconsistent with biological expectations. By using the biological inconsistencies as our motivation, we present a reformulated statistical method for estimating preferential pairing, and use this method to reanalyze the same autotetraploid alfalfa data and to conduct a simulation study. Our results directly contradict the current findings of significant preferential pairing and affirm the traditional view of random chromosome segregation in alfalfa. 
ER  -