@article{Cao01032004,
author = {Cao, Dachuang and Osborn, Thomas C. and Doerge, Rebecca W.}, 
title = {Correct Estimation of Preferential Chromosome Pairing in Autotetraploids},
volume = {14}, 
number = {3}, 
pages = {459-462}, 
year = {2004}, 
doi = {10.1101/gr.1596604}, 
abstract ={In recent work, a statistical model was proposed for the purpose of estimating parameters associated with quantitative trait locus (QTL) mapping and preferential pairing within a polyploidy framework. The statistical model contained several parameters that, when estimated from experimental data, supplied information about QTL, including a preferential pairing factor. Among the results reported were estimates of preferential pairing, many of which indicated high levels of preferential pairing (p = 0.60) that were inconsistent with biological expectations. By using the biological inconsistencies as our motivation, we present a reformulated statistical method for estimating preferential pairing, and use this method to reanalyze the same autotetraploid alfalfa data and to conduct a simulation study. Our results directly contradict the current findings of significant preferential pairing and affirm the traditional view of random chromosome segregation in alfalfa.}, 
URL = {http://genome.cshlp.org/content/14/3/459.abstract}, 
eprint = {http://genome.cshlp.org/content/14/3/459.full.pdf+html}, 
journal = {Genome Research} 
}