@article{Prinz01032004,
author = {Prinz, Susanne and Avila-Campillo, Iliana and Aldridge, Christine and Srinivasan, Ajitha and Dimitrov, Krassen and Siegel, Andrew F. and Galitski, Timothy}, 
title = {Control of Yeast Filamentous-Form Growth by Modules in an Integrated Molecular Network},
volume = {14}, 
number = {3}, 
pages = {380-390}, 
year = {2004}, 
doi = {10.1101/gr.2020604}, 
abstract ={On solid growth media with limiting nitrogen source, diploid budding-yeast cells differentiate from the yeast form to a filamentous, adhesive, and invasive form. Genomic profiles of mRNA levels in Saccharomyces cerevisiae yeast-form and filamentous-form cells were compared. Disparate data types, including genes implicated by expression change, filamentation genes known previously through a phenotype, protein–protein interaction data, and protein–metabolite interaction data were integrated as the nodes and edges of a filamentation-network graph. Application of a network-clustering method revealed 47 clusters in the data. The correspondence of the clusters to modules is supported by significant coordinated expression change among cluster co-member genes, and the quantitative identification of collective functions controlling cell properties. The modular abstraction of the filamentation network enables the association of filamentous-form cell properties with the activation or repression of specific biological processes, and suggests hypotheses. A module-derived hypothesis was tested. It was found that the 26S proteasome regulates filamentous-form growth.}, 
URL = {http://genome.cshlp.org/content/14/3/380.abstract}, 
eprint = {http://genome.cshlp.org/content/14/3/380.full.pdf+html}, 
journal = {Genome Research} 
}