RT Journal
A1 Veeramachaneni, Vamsi
A1 Makalowski, Wojciech
A1 Galdzicki, Michal
A1 Sood, Raman
A1 Makalowska, Izabela
T1 Mammalian Overlapping Genes: The Comparative Perspective
JF Genome Research 
JO Genome Research 
YR 2004 
FD February 01 
VO 14 
IS 2 
SP 280 
OP 286 
DO 10.1101/gr.1590904 
UL http://genome.cshlp.org/content/14/2/280.abstract 
AB It is believed that 3.2 billion bp of the human genome harbor ∼35,000 protein-coding genes. On average, one could expect one gene per 300,000 nucleotides (nt). Although the distribution of the genes in the human genome is not random,it is rather surprising that a large number of genes overlap in the mammalian genomes. Thousands of overlapping genes were recently identified in the human and mouse genomes. However,the origin and evolution of overlapping genes are still unknown. We identified 1316 pairs of overlapping genes in humans and mice and studied their evolutionary patterns. It appears that these genes do not demonstrate greater than usual conservation. Studies of the gene structure and overlap pattern showed that only a small fraction of analyzed genes preserved exactly the same pattern in both organisms.