TY  - JOUR
A1  - Veeramachaneni, Vamsi
A1  - Makalowski, Wojciech
A1  - Galdzicki, Michal
A1  - Sood, Raman
A1  - Makalowska, Izabela
T1  - Mammalian Overlapping Genes: The Comparative Perspective
Y1  - 2004/02/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 280 
EP  - 286 
DO  - 10.1101/gr.1590904 
VL  - 14 
IS  - 2 
UR  - http://genome.cshlp.org/content/14/2/280.abstract 
N2  - It is believed that 3.2 billion bp of the human genome harbor ∼35,000 protein-coding genes. On average, one could expect one gene per 300,000 nucleotides (nt). Although the distribution of the genes in the human genome is not random,it is rather surprising that a large number of genes overlap in the mammalian genomes. Thousands of overlapping genes were recently identified in the human and mouse genomes. However,the origin and evolution of overlapping genes are still unknown. We identified 1316 pairs of overlapping genes in humans and mice and studied their evolutionary patterns. It appears that these genes do not demonstrate greater than usual conservation. Studies of the gene structure and overlap pattern showed that only a small fraction of analyzed genes preserved exactly the same pattern in both organisms. 
ER  -