TY  - JOUR
A1  - Versteeg,, Rogier
A1  - van Schaik, Barbera D.C.
A1  - van Batenburg, Marinus F.
A1  - Roos, Marco
A1  - Monajemi, Ramin
A1  - Caron, Huib
A1  - Bussemaker, Harmen J.
A1  - van Kampen, Antoine H.C.
T1  - The Human Transcriptome Map Reveals Extremes in Gene Density, Intron Length, GC Content, and Repeat Pattern for Domains of Highly and Weakly Expressed Genes
Y1  - 2003/09/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1998 
EP  - 2004 
DO  - 10.1101/gr.1649303 
VL  - 13 
IS  - 9 
UR  - http://genome.cshlp.org/content/13/9/1998.abstract 
N2  - The chromosomal gene expression profiles established by the Human  Transcriptome Map (HTM) revealed a clustering of highly expressed genes in  about 30 domains, called ridges. To physically characterize ridges, we  constructed a new HTM based on the draft human genome sequence (HTMseq).  Expression of 25,003 genes can be analyzed online in a multitude of tissues  (http://bioinfo.amc.uva.nl/HTMseq).  Ridges are found to be very gene-dense domains with a high GC content, a high  SINE repeat density, and a low LINE repeat density. Genes in ridges have  significantly shorter introns than genes outside of ridges. The HTMseq also  identifies a significant clustering of weakly expressed genes in domains with  fully opposite characteristics (antiridges). Both types of domains are open to  tissue-specific expression regulation, but the maximal expression levels in  ridges are considerably higher than in antiridges. Ridges are therefore an  integral part of a higher order structure in the genome related to  transcriptional regulation. 
ER  -