@article{Versteeg,01092003,
author = {Versteeg,, Rogier and van Schaik, Barbera D.C. and van Batenburg, Marinus F. and Roos, Marco and Monajemi, Ramin and Caron, Huib and Bussemaker, Harmen J. and van Kampen, Antoine H.C.}, 
title = {The Human Transcriptome Map Reveals Extremes in Gene Density, Intron Length, GC Content, and Repeat Pattern for Domains of Highly and Weakly Expressed Genes},
volume = {13}, 
number = {9}, 
pages = {1998-2004}, 
year = {2003}, 
doi = {10.1101/gr.1649303}, 
abstract ={The chromosomal gene expression profiles established by the Human  Transcriptome Map (HTM) revealed a clustering of highly expressed genes in  about 30 domains, called ridges. To physically characterize ridges, we  constructed a new HTM based on the draft human genome sequence (HTMseq).  Expression of 25,003 genes can be analyzed online in a multitude of tissues  (http://bioinfo.amc.uva.nl/HTMseq).  Ridges are found to be very gene-dense domains with a high GC content, a high  SINE repeat density, and a low LINE repeat density. Genes in ridges have  significantly shorter introns than genes outside of ridges. The HTMseq also  identifies a significant clustering of weakly expressed genes in domains with  fully opposite characteristics (antiridges). Both types of domains are open to  tissue-specific expression regulation, but the maximal expression levels in  ridges are considerably higher than in antiridges. Ridges are therefore an  integral part of a higher order structure in the genome related to  transcriptional regulation.}, 
URL = {http://genome.cshlp.org/content/13/9/1998.abstract}, 
eprint = {http://genome.cshlp.org/content/13/9/1998.full.pdf+html}, 
journal = {Genome Research} 
}