RT Journal
A1 Bajic, Vladimir B.
A1 Seah, Seng Hong
T1 Dragon Gene Start Finder: An Advanced System for Finding Approximate Locations of the Start of Gene Transcriptional Units
JF Genome Research 
JO Genome Research 
YR 2003 
FD August 01 
VO 13 
IS 8 
SP 1923 
OP 1929 
DO 10.1101/gr.869803 
UL http://genome.cshlp.org/content/13/8/1923.abstract 
AB We present an advanced system for recognition of gene starts in mammalian  genomes. The system makes predictions of gene start location by combining  information about CpG islands, transcription start sites (TSSs), and signals  downstream of the predicted TSSs. The system aims at predicting a region that  contains the gene start or is in its proximity. Evaluation on human  chromosomes 4, 21, and 22 resulted in Se of over 65% and in a ppv of ∼78%.  The system makes on average one prediction per 177,000 nucleotides on the  human genome, as judged by the results on chromosome 21. Comparison of  abilities to predict TSS with the two other systems on human chromosomes 4,  21, and 22 reveals that our system has superior accuracy and overall provides  the most confident predictions.