RT Journal
A1 Owen, Art B.
A1 Stuart, Josh
A1 Mach, Kathy
A1 Villeneuve, Anne M.
A1 Kim, Stuart
T1 A Gene Recommender Algorithm to Identify Coexpressed Genes in C.  elegans
JF Genome Research 
JO Genome Research 
YR 2003 
FD August 01 
VO 13 
IS 8 
SP 1828 
OP 1837 
DO 10.1101/gr.1125403 
UL http://genome.cshlp.org/content/13/8/1828.abstract 
AB One of the most important uses of whole-genome expression data is for the  discovery of new genes with similar function to a given list of genes (the  query) already known to have closely related function. We have developed an  algorithm, called the gene recommender, that ranks genes according to how  strongly they correlate with a set of query genes in those experiments for  which the query genes are most strongly coregulated. We used the gene  recommender to find other genes coexpressed with several sets of query genes,  including genes known to function in the retinoblastoma complex. Genetic  experiments confirmed that one gene (JC8.6) identified by the gene recommender  acts with lin-35 Rb to regulate vulval cell fates, and that another  gene (wrm-1) acts antagonistically. We find that the gene recommender  returns lists of genes with better precision, for fixed levels of recall, than  lists generated using the C. elegans expression topomap.