TY  - JOUR
A1  - Jaillon, Olivier
A1  - Dossat, Carole
A1  - Eckenberg, Ralph
A1  - Eiglmeier, Karin
A1  - Segurens, Béatrice
A1  - Aury, Jean-Marc
A1  - Roth, Charles W.
A1  - Scarpelli, Claude
A1  - Brey, Paul T.
A1  - Weissenbach, Jean
A1  - Wincker, Patrick
T1  - Assessing the Drosophila melanogaster and Anopheles
 gambiae Genome Annotations Using Genome-Wide Sequence Comparisons
Y1  - 2003/07/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1595 
EP  - 1599 
DO  - 10.1101/gr.922503 
VL  - 13 
IS  - 7 
UR  - http://genome.cshlp.org/content/13/7/1595.abstract 
N2  - We performed genome-wide sequence comparisons at the protein coding level
 between the genome sequences of Drosophila melanogaster and
 Anopheles gambiae. Such comparisons detect evolutionarily conserved
 regions (ecores) that can be used for a qualitative and quantitative
 evaluation of the available annotations of both genomes. They also provide
 novel candidate features for annotation. The percentage of ecores mapping
 outside annotations in the A. gambiae genome is about fourfold higher
 than in D. melanogaster. The A. gambiae genome assembly also
 contains a high proportion of duplicated ecores, possibly resulting from
 artefactual sequence duplications in the genome assembly. The occurrence of
 4063 ecores in the D. melanogaster genome outside annotations
 suggests that some genes are not yet or only partially annotated. The present
 work illustrates the power of comparative genomics approaches towards an
 exhaustive and accurate establishment of gene models and gene catalogues in
 insect genomes. 
ER  -