@article{Jaillon01072003,
author = {Jaillon, Olivier and Dossat, Carole and Eckenberg, Ralph and Eiglmeier, Karin and Segurens, Béatrice and Aury, Jean-Marc and Roth, Charles W. and Scarpelli, Claude and Brey, Paul T. and Weissenbach, Jean and Wincker, Patrick}, 
title = {Assessing the Drosophila melanogaster and Anopheles
 gambiae Genome Annotations Using Genome-Wide Sequence Comparisons},
volume = {13}, 
number = {7}, 
pages = {1595-1599}, 
year = {2003}, 
doi = {10.1101/gr.922503}, 
abstract ={We performed genome-wide sequence comparisons at the protein coding level
 between the genome sequences of Drosophila melanogaster and
 Anopheles gambiae. Such comparisons detect evolutionarily conserved
 regions (ecores) that can be used for a qualitative and quantitative
 evaluation of the available annotations of both genomes. They also provide
 novel candidate features for annotation. The percentage of ecores mapping
 outside annotations in the A. gambiae genome is about fourfold higher
 than in D. melanogaster. The A. gambiae genome assembly also
 contains a high proportion of duplicated ecores, possibly resulting from
 artefactual sequence duplications in the genome assembly. The occurrence of
 4063 ecores in the D. melanogaster genome outside annotations
 suggests that some genes are not yet or only partially annotated. The present
 work illustrates the power of comparative genomics approaches towards an
 exhaustive and accurate establishment of gene models and gene catalogues in
 insect genomes.}, 
URL = {http://genome.cshlp.org/content/13/7/1595.abstract}, 
eprint = {http://genome.cshlp.org/content/13/7/1595.full.pdf+html}, 
journal = {Genome Research} 
}