TY  - JOUR
A1  - Suzuki, Harukazu
A1  - Saito, Rintaro
A1  - Kanamori, Mutsumi
A1  - Kai, Chikatoshi
A1  - Schönbach, Christian
A1  - Nagashima, Takeshi
A1  - Hosaka, Junko
A1  - Hayashizaki, Yoshihide
T1  - The Mammalian Protein–Protein Interaction Database and Its Viewing System That Is Linked to the Main FANTOM2 Viewer
Y1  - 2003/06/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1534 
EP  - 1541 
DO  - 10.1101/gr.956303 
VL  - 13 
IS  - 6b 
UR  - http://genome.cshlp.org/content/13/6b/1534.abstract 
N2  - Here, we describe the development of a mammalian protein–protein  interaction (PPI) database and of a PPI Viewer application to display protein  interaction networks  (http://fantom21.gsc.riken.go.jp/PPI/).  In the database, we stored the mammalian PPIs identified through our PPI  assays (internal PPIs), as well as those we extracted and processed (external  PPIs) from publicly available data sources, the DIP and BIND databases and  MEDLINE abstracts by using FACTS, a new functional inference and curation  system. We integrated the internal and external PPIs into the PPI database,  which is linked to the main FANTOM2 viewer. In addition, we incorporated into  the PPI Viewer information regarding the luciferase reporter activity of  internal PPIs and the data confidence of external PPIs; these data enable  visualization and evaluation of the reliability of each interaction. Using the  described system, we successfully identified several interactions of  biological significance. Therefore, the PPI Viewer is a useful tool for  exploring FANTOM2 clone-related protein interactions and their potential  effects on signaling and cellular communication. 
ER  -