RT Journal
A1 Kawai, Jun
A1 Hayashizaki, Yoshihide
T1 DNA Book
JF Genome Research 
JO Genome Research 
YR 2003 
FD June 01 
VO 13 
IS 6b 
SP 1488 
OP 1495 
DO 10.1101/gr.914203 
UL http://genome.cshlp.org/content/13/6b/1488.abstract 
AB We propose herein a new method of DNA distribution, whereby DNA clones or  PCR products are printed directly onto the pages of books and delivered to  users along with relevant scientific information. DNA sheets, comprising  water-soluble paper onto which DNA is spotted, can be bound into books.  Readers can easily extract the DNA fragments from DNA sheets and amplify them  using PCR. We show that DNA sheets can withstand various conditions that may  be experienced during bookbinding and delivery, such as high temperatures and  humidity. Almost all genes (95%–100% of randomly selected RIKEN mouse  cDNA clones) were recovered successfully by use of PCR. Readers can start  their experiments after a 2-h PCR amplification without waiting for the  delivery of DNA clones. The DNA Book thus provides a novel method for  delivering DNA in a timely and cost-effective manner. A sample DNA sheet  (carrying RIKEN mouse cDNA clones encoding genes of enzymes for the TCA cycle)  is included in this issue for field-testing. We would greatly appreciate it if  readers could attempt to extract DNA and report the results and whether the  DNA sheet was shipped to readers in good condition.