RT Journal
A1 Grimmond, Sean M.
A1 Miranda, Kevin C.
A1 Yuan, Zheng
A1 Davis, Melissa J.
A1 Hume, David A.
A1 Yagi, Ken
A1 Tominaga, Naoko
A1 Bono, Hidemasa
A1 Hayashizaki, Yoshihide
A1 Okazaki, Yasushi
A1 RIKEN GER Group
A1 GSL Members
A1 Teasdale, Rohan D.
T1 The Mouse Secretome: Functional Classification of the Proteins Secreted Into the Extracellular Environment
JF Genome Research 
JO Genome Research 
YR 2003 
FD June 01 
VO 13 
IS 6b 
SP 1350 
OP 1359 
DO 10.1101/gr.983703 
UL http://genome.cshlp.org/content/13/6b/1350.abstract 
AB We have developed a computational strategy to identify the set of soluble  proteins secreted into the extracellular environment of a cell. Within the  protein sequences predominantly derived from the RIKEN representative  transcript and protein set, we identified 2033 unique soluble proteins that  are potentially secreted from the cell. These proteins contain a signal  peptide required for entry into the secretory pathway and lack any  transmembrane domains or intracellular localization signals. This class of  proteins, which we have termed the mouse secretome, included >500 novel  proteins and 92 proteins <100 amino acids in length. Functional analysis of  the secretome included identification of human orthologs, functional units  based on InterPro and SCOP Superfamily predictions, and expression of the  proteins within the RIKEN READ microarray database. To highlight the utility  of this information, we discuss the CUB domain-containing protein family.