RT Journal
A1 Koike, Asako
A1 Kobayashi, Yoshiyuki
A1 Takagi, Toshihisa
T1 Kinase Pathway Database: An Integrated Protein-Kinase and NLP-Based Protein-Interaction Resource
JF Genome Research 
JO Genome Research 
YR 2003 
FD June 01 
VO 13 
IS 6a 
SP 1231 
OP 1243 
DO 10.1101/gr.835903 
UL http://genome.cshlp.org/content/13/6a/1231.abstract 
AB Protein kinases play a crucial role in the regulation of cellular  functions. Various kinds of information about these molecules are important  for understanding signaling pathways and organism characteristics. We have  developed the Kinase Pathway Database, an integrated database involving major  completely sequenced eukaryotes. It contains the classification of protein  kinases and their functional conservation, ortholog tables among species,  protein–protein, protein–gene, and protein–compound  interaction data, domain information, and structural information. It also  provides an automatic pathway graphic image interface. The protein, gene, and  compound interactions are automatically extracted from abstracts for all genes  and proteins by natural-language processing (NLP).The method of automatic  extraction uses phrase patterns and the GENA protein, gene, and compound name  dictionary, which was developed by our group. With this database, pathways are  easily compared among species using data with more than 47,000 protein  interactions and protein kinase ortholog tables. The database is available for  querying and browsing at  http://kinasedb.ontology.ims.u-tokyo.ac.jp/.