RT Journal A1 O'Brien, Timothy P. A1 Bult, Carol J. A1 Cremer, Christoph A1 Grunze, Michael A1 Knowles, Barbara B. A1 Langowski, Jörg A1 McNally, James A1 Pederson, Thoru A1 Politz, Joan C. A1 Pombo, Ana A1 Schmahl, Günter A1 Spatz, Joachim P. A1 van Driel, Roel T1 Genome Function and Nuclear Architecture: From Gene Expression to Nanoscience JF Genome Research JO Genome Research YR 2003 FD June 01 VO 13 IS 6a SP 1029 OP 1041 DO 10.1101/gr.946403 UL http://genome.cshlp.org/content/13/6a/1029.abstract AB Biophysical, chemical, and nanoscience approaches to the study of nuclear structure and activity have been developing recently and hold considerable promise. A selection of fundamental problems in genome organization and function are reviewed and discussed in the context of these new perspectives and approaches. Advancing these concepts will require coordinated networks of physicists, chemists, and materials scientists collaborating with cell, developmental, and genome biologists.