TY - JOUR A1 - Giardine, Belinda A1 - Elnitski, Laura A1 - Riemer, Cathy A1 - Makalowska, Izabela A1 - Schwartz, Scott A1 - Miller, Webb A1 - Hardison, Ross C. T1 - GALA, a Database for Genomic Sequence Alignments and Annotations Y1 - 2003/04/01 JF - Genome Research JO - Genome Research SP - 732 EP - 741 DO - 10.1101/gr.603103 VL - 13 IS - 4 UR - http://genome.cshlp.org/content/13/4/732.abstract N2 - We have developed a relational database to contain whole genome sequence alignments between human and mouse with extensive annotations of the human sequence. Complex queries are supported on recorded features, both directly and on proximity among them. Searches can reveal a wide variety of relationships, such as finding all genes expressed in a designated tissue that have a highly conserved noncoding sequence 5′ to the start site. Other examples are finding single nucleotide polymorphisms that occur in conserved noncoding regions upstream of genes and identifying CpG islands that overlap the 5′ ends of divergently transcribed genes. The database is available online athttp://globin.cse.psu.edu/ and http://bio.cse.psu.edu/. ER -