TY  - JOUR
A1  - Takada, Toyoyuki
A1  - Kumánovics, Attila
A1  - Amadou, Claire
A1  - Yoshino, Masayasu
A1  - Jones, Elsy P.
A1  - Athanasiou, Maria
A1  - Evans, Glen A.
A1  - Lindahl, Kirsten Fischer
T1  - Species-Specific Class I Gene Expansions Formed the Telomeric 1 Mb of the Mouse Major Histocompatibility Complex
Y1  - 2003/04/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 589 
EP  - 600 
DO  - 10.1101/gr.975303 
VL  - 13 
IS  - 4 
UR  - http://genome.cshlp.org/content/13/4/589.abstract 
N2  - We have determined the complete sequence of 951,695 bp from the class I region of H2, the mouse major histocompatibility complex (Mhc) from strain 129/Sv (haplotype bc). The sequence contains 26 genes. The sequence spans from the last 50 kb of the H2-T region, including 2 class I genes and 3 class I pesudogenes, and includes the H2-M region up toGabbr1. A 500-kb stretch of the H2-M region contains 9 class I genes and 4 pseudogenes, which fall into two subfamilies,M1 and M10, distinct from other mouse class I genes. This M1/M10 class I gene-cluster is separated from the centromeric H2-T and the telomeric H2-M4, -5 and-6 class I genes by “nonclass I genes”. Comparison with the corresponding 853-kb region of the human Mhc, which includes the HLA-A region, shows a mosaic of conserved regions of orthologous nonclass I genes separated by regions of species-specific expansion of paralogous Mhc class I genes. The analysis of this mosaic structure illuminates the dynamic evolution of the Mhc class I region among mammals and provides evidence for the framework hypothesis.[Supplemental material is available online at www.genome.org. The sequence data from this study have been submitted to GenBank under accession nos. AC005413, AC005665,AF532111–AF532117. A preliminary draft sequence was earlier submitted as AC002615 and replaced this year by NT002615.] 
ER  -