RT Journal
A1 Woram, Rachael A.
A1 Gharbi, Karim
A1 Sakamoto, Takashi
A1 Hoyheim, Bjorn
A1 Holm, Lars-Erik
A1 Naish, Kerry
A1 McGowan, Colin
A1 Ferguson, Moira M.
A1 Phillips, Ruth B.
A1 Stein, Jake
A1 Guyomard, René
A1 Cairney, Margaret
A1 Taggart, John B.
A1 Powell, Richard
A1 Davidson, William
A1 Danzmann, Roy G.
T1 Comparative Genome Analysis of the Primary Sex-Determining Locus in Salmonid Fishes
JF Genome Research 
JO Genome Research 
YR 2003 
FD February 01 
VO 13 
IS 2 
SP 272 
OP 280 
DO 10.1101/gr.578503 
UL http://genome.cshlp.org/content/13/2/272.abstract 
AB We compared the Y-chromosome linkage maps for four salmonid species (Arctic charr, Salvelinus alpinus; Atlantic salmon, Salmo salar; brown trout, Salmo trutta; and rainbow trout,Oncorhynchus mykiss) and a putative Y-linked marker from lake trout (Salvelinus namaycush). These species represent the three major genera within the subfamily Salmoninae of the Salmonidae. The data clearly demonstrate that different Y-chromosomes have evolved in each of the species. Arrangements of markers proximal to the sex-determining locus are preserved on homologous, but different, autosomal linkage groups across the four species studied in detail. This indicates that a small region of DNA has been involved in the rearrangement of the sex-determining region. Placement of the sex-determining region appears telomeric in brown trout, Atlantic salmon, and Arctic charr, whereas an intercalary location forSEX may exist in rainbow trout. Three hypotheses are proposed to account for the relocation: translocation of a small chromosome arm; transposition of the sex-determining gene; or differential activation of a primary sex-determining gene region among the species.