RT Journal
A1 Arita, Masanori
T1 In Silico Atomic Tracing by Substrate-Product Relationships in Escherichia coli Intermediary Metabolism
JF Genome Research 
JO Genome Research 
YR 2003 
FD November 01 
VO 13 
IS 11 
SP 2455 
OP 2466 
DO 10.1101/gr.1212003 
UL http://genome.cshlp.org/content/13/11/2455.abstract 
AB We present a software system that computationally reproduces biochemical radioisotope-tracer experiments. It consists of three main components: A mapping database of substrate-product atomic correspondents derived from known reaction formulas, a tracing engine that can compute all pathways between two given compounds by using the mapping database, and a graphical user interface. As the system can facilitate the display of all possible pathways between any two compounds and the tracing of every single carbon, nitrogen, or sulfur atom in the metabolism, it complements and bridges other metabolic databases and simulations on fixed models.