RT Journal
A1 Dezső, Zoltán
A1 Oltvai, Zoltán N.
A1 Barabási, Albert-László
T1 Bioinformatics Analysis of Experimentally Determined Protein Complexes in the Yeast Saccharomyces cerevisiae
JF Genome Research 
JO Genome Research 
YR 2003 
FD November 01 
VO 13 
IS 11 
SP 2450 
OP 2454 
DO 10.1101/gr.1073603 
UL http://genome.cshlp.org/content/13/11/2450.abstract 
AB Many important cellular functions are implemented by protein complexes that act as sophisticated molecular machines of varying size and temporal stability. Here we demonstrate quantitatively that protein complexes in the yeast Saccharomyces cerevisiae are comprised of a core in which subunits are highly coexpressed, display the same deletion phenotype (essential or nonessential), and share identical functional classification and cellular localization. This core is surrounded by a functionally mixed group of proteins, which likely represent short-lived or spurious attachments. The results allow us to define the deletion phenotype and cellular task of most known complexes, and to identify with high confidence the biochemical role of hundreds of proteins with yet unassigned functionality.