TY - JOUR A1 - Peri, Suraj A1 - Navarro, J. Daniel A1 - Amanchy, Ramars A1 - Kristiansen, Troels Z. A1 - Jonnalagadda, Chandra Kiran A1 - Surendranath, Vineeth A1 - Niranjan, Vidya A1 - Muthusamy, Babylakshmi A1 - Gandhi, T.K.B. A1 - Gronborg, Mads A1 - Ibarrola, Nieves A1 - Deshpande, Nandan A1 - Shanker, K. A1 - Shivashankar, H.N. A1 - Rashmi, B.P. A1 - Ramya, M.A. A1 - Zhao, Zhixing A1 - Chandrika, K.N. A1 - Padma, N. A1 - Harsha, H.C. A1 - Yatish, A.J. A1 - Kavitha, M.P. A1 - Menezes, Minal A1 - Choudhury, Dipanwita Roy A1 - Suresh, Shubha A1 - Ghosh, Neelanjana A1 - Saravana, R. A1 - Chandran, Sreenath A1 - Krishna, Subhalakshmi A1 - Joy, Mary A1 - Anand, Sanjeev K. A1 - Madavan, V. A1 - Joseph, Ansamma A1 - Wong, Guang W. A1 - Schiemann, William P. A1 - Constantinescu, Stefan N. A1 - Huang, Lily A1 - Khosravi-Far, Roya A1 - Steen, Hanno A1 - Tewari, Muneesh A1 - Ghaffari, Saghi A1 - Blobe, Gerard C. A1 - Dang, Chi V. A1 - Garcia, Joe G.N. A1 - Pevsner, Jonathan A1 - Jensen, Ole N. A1 - Roepstorff, Peter A1 - Deshpande, Krishna S. A1 - Chinnaiyan, Arul M. A1 - Hamosh, Ada A1 - Chakravarti, Aravinda A1 - Pandey, Akhilesh T1 - Development of Human Protein Reference Database as an Initial Platform for Approaching Systems Biology in Humans Y1 - 2003/10/01 JF - Genome Research JO - Genome Research SP - 2363 EP - 2371 DO - 10.1101/gr.1680803 VL - 13 IS - 10 UR - http://genome.cshlp.org/content/13/10/2363.abstract N2 - Human Protein Reference Database (HPRD) is an object database that integrates a wealth of information relevant to the function of human proteins in health and disease. Data pertaining to thousands of protein-protein interactions, posttranslational modifications, enzyme/substrate relationships, disease associations, tissue expression, and subcellular localization were extracted from the literature for a nonredundant set of 2750 human proteins. Almost all the information was obtained manually by biologists who read and interpreted >300,000 published articles during the annotation process. This database, which has an intuitive query interface allowing easy access to all the features of proteins, was built by using open source technologies and will be freely available at http://www.hprd.org to the academic community. This unified bioinformatics platform will be useful in cataloging and mining the large number of proteomic interactions and alterations that will be discovered in the postgenomic era. ER -