@article{Rowe01012003, author = {Rowe, Lucy B. and Barter, Mary E. and Kelmenson, Jennifer A. and Eppig, Janan T.}, title = {The Comprehensive Mouse Radiation Hybrid Map Densely Cross-Referenced to the Recombination Map: A Tool to Support the Sequence Assemblies}, volume = {13}, number = {1}, pages = {122-133}, year = {2003}, doi = {10.1101/gr.858103}, abstract ={We have developed a unique comprehensive mouse radiation hybrid (RH) map of nearly 23,000 markers integrating data from three international genome centers and over 400 independent laboratories. We have cross-referenced this map to the 0.5-cM resolution recombination-based Jackson Laboratory (TJL) backcross panel map, building a complete set of RH framework chromosome maps based on a high density of known-ordered anchor markers. We have systematically typed markers to improve coverage and resolve discrepancies, and have reanalyzed data sets as needed. The cross-linking of the RH and recombination maps has resulted in a highly accurate genome-wide map with consistent marker order. We have compared these linked framework maps to the Ensembl mouse genome sequence assembly, and show that they are a useful medium resolution tool for both validating sequence assembly and elucidating chromosome biology.[Supplemental material is available online at www.genome.org.]}, URL = {http://genome.cshlp.org/content/13/1/122.abstract}, eprint = {http://genome.cshlp.org/content/13/1/122.full.pdf+html}, journal = {Genome Research} }