RT Journal
A1 Frazer, Kelly A.
A1 Elnitski, Laura
A1 Church, Deanna M.
A1 Dubchak, Inna
A1 Hardison, Ross C.
T1 Cross-Species Sequence Comparisons: A Review of Methods and Available Resources
JF Genome Research 
JO Genome Research 
YR 2003 
FD January 01 
VO 13 
IS 1 
SP 1 
OP 12 
DO 10.1101/gr.222003 
UL http://genome.cshlp.org/content/13/1/1.abstract 
AB With the availability of whole-genome sequences for an increasing number of species, we are now faced with the challenge of decoding the information contained within these DNA sequences. Comparative analysis of DNA sequences from multiple species at varying evolutionary distances is a powerful approach for identifying coding and functional noncoding sequences, as well as sequences that are unique for a given organism. In this review, we outline the strategy for choosing DNA sequences from different species for comparative analyses and describe the methods used and the resources publicly available for these studies.