TY - JOUR A1 - Yu, Jun A1 - Yang, Zhiyong A1 - Kibukawa, Miho A1 - Paddock, Marcia A1 - Passey, Douglas A. A1 - Wong, Gane Ka-Shu T1 - Minimal Introns Are Not “Junk” Y1 - 2002/08/01 JF - Genome Research JO - Genome Research SP - 1185 EP - 1189 DO - 10.1101/gr.224602 VL - 12 IS - 8 UR - http://genome.cshlp.org/content/12/8/1185.abstract N2 - Intron-size distributions for most multicellular (and some unicellular) eukaryotes have a sharp peak at their “minimal intron” size. Across the human population, these minimal introns exhibit an abundance of insertion-deletion polymorphisms, the effect of which is to maintain their optimal size. We argue that minimal introns affect function by enhancing the rate at which mRNA is exported from the cell nucleus. ER -