TY  - JOUR
A1  - Brinkman, Fiona S.L.
A1  - Blanchard, Jeffrey L.
A1  - Cherkasov, Artem
A1  - Av-Gay, Yossef
A1  - Brunham, Robert C.
A1  - Fernandez, Rachel C.
A1  - Finlay, B. Brett
A1  - Otto, Sarah P.
A1  - Ouellette, B.F. Francis
A1  - Keeling, Patrick J.
A1  - Rose, Ann M.
A1  - Hancock, Robert E.W.
A1  - Jones, Steven J.M.
T1  - Evidence That Plant-Like Genes in Chlamydia Species Reflect an Ancestral Relationship between Chlamydiaceae, Cyanobacteria, and the Chloroplast
Y1  - 2002/08/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1159 
EP  - 1167 
DO  - 10.1101/gr.341802 
VL  - 12 
IS  - 8 
UR  - http://genome.cshlp.org/content/12/8/1159.abstract 
N2  - An unusually high proportion of proteins encoded inChlamydia genomes are most similar to plant proteins, leading to proposals that a Chlamydia ancestor obtained genes from a plant or plant-like host organism by horizontal gene transfer. However, during an analysis of bacterial–eukaryotic protein similarities, we found that the vast majority of plant-like sequences in Chlamydia are most similar to plant proteins that are targeted to the chloroplast, an organelle derived from a cyanobacterium. We present further evidence suggesting that plant-like genes in Chlamydia, and other Chlamydiaceae, are likely a reflection of an unappreciated evolutionary relationship between the Chlamydiaceae and the cyanobacteria-chloroplast lineage. Further analyses of bacterial and eukaryotic genomes indicates the importance of evaluating organellar ancestry of eukaryotic proteins when identifying bacteria-eukaryote homologs or horizontal gene transfer and supports the proposal that Chlamydiaceae, which are obligate intracellular bacterial pathogens of animals, are not likely exchanging DNA with their hosts.[Supplementary Material is available online at http://www.genome.org and athttp://www.pathogenomics.bc.ca/BAE-watch.html.] 
ER  -