RT Journal
A1 Borštnik, Branko
A1 Pumpernik, Danilo
T1 Tandem Repeats in Protein Coding Regions of Primate Genes
JF Genome Research 
JO Genome Research 
YR 2002 
FD June 01 
VO 12 
IS 6 
SP 909 
OP 915 
DO 10.1101/gr.138802 
UL http://genome.cshlp.org/content/12/6/909.abstract 
AB Tandem repeats in GenBank primate nucleotide sequences annotated as protein coding regions are analyzed. It is found that only trinucleotide repeats show repeat enrichment well above the threshold of statistical significance. The statistics are improved by a simultaneous search for repeats on both the amino acid and nucleotide levels. The results of the analyses of natural sequences are interpreted by comparing them with the results of the computer simulation of the model dedicated to protein coding regions. According to the simulation results, a limited set of trinucleotides, that is, cgg, ccg, cag, and gaa repeats coding for polyalanine, polyglycine, polyproline, polyglutamine, and polylysine are prone to proliferation. It is also found that within the repeat regions slippage is more frequent by a factor of 10 than point mutations, whereas the ratio of silent versus recognizable point mutations is approximately the same as elsewhere in coding regions. The trinucleotide repeats cover slightly more than 0.3% of the protein coding regions of genes.