@article{Wang01052002, author = {Wang, Jun and Wong, Gane Ka-Shu and Ni, Peixiang and Han, Yujun and Huang, Xiangang and Zhang, Jianguo and Ye, Chen and Zhang, Yong and Hu, Jianfei and Zhang, Kunlin and Xu, Xin and Cong, Lijuan and Lu, Hong and Ren, Xide and Ren, Xiaoyu and He, Jun and Tao, Lin and Passey, Douglas A. and Wang, Jian and Yang, Huanming and Yu, Jun and Li, Songgang}, title = { RePS: A Sequence Assembler That Masks Exact Repeats Identified from the Shotgun Data}, volume = {12}, number = {5}, pages = {824-831}, year = {2002}, doi = {10.1101/gr.165102}, abstract ={We describe a sequence assembler, RePS(repeat-masked Phrap with scaffolding), that explicitly identifies exact 20mer repeats from the shotgun data and removes them prior to the assembly. The established software Phrap is used to compute meaningful error probabilities for each base. Clone-end-pairing information is used to construct scaffolds that order and orient the contigs. We show with real data for human and rice that reasonable assemblies are possible even at coverages of only 4× to 6×, despite having up to 42.2% in exact repeats.[The following individuals kindly provided reagents, samples, or unpublished information as indicated in the paper: P. Green and A.F. Smit.]}, URL = {http://genome.cshlp.org/content/12/5/824.abstract}, eprint = {http://genome.cshlp.org/content/12/5/824.full.pdf+html}, journal = {Genome Research} }