RT Journal
A1 Livesay, Eric A.
A1 Liu, Ying-Horng
A1 Luebke, Kevin J.
A1 Irick, Joel
A1 Belosludtsev, Yuri
A1 Rayner, Simon
A1 Balog, Robert
A1 Johnston, Stephen Albert
T1 A Scalable High-Throughput Chemical Synthesizer
JF Genome Research 
JO Genome Research 
YR 2002 
FD December 01 
VO 12 
IS 12 
SP 1950 
OP 1960 
DO 10.1101/gr.359002 
UL http://genome.cshlp.org/content/12/12/1950.abstract 
AB A machine that employs a novel reagent delivery technique for biomolecular synthesis has been developed. This machine separates the addressing of individual synthesis sites from the actual process of reagent delivery by using masks placed over the sites. Because of this separation, this machine is both cost-effective and scalable, and thus the time required to synthesize 384 or 1536 unique biomolecules is very nearly the same. Importantly, the mask design allows scaling of the number of synthesis sites without the addition of new valving. Physical and biological comparisons between DNA made on a commercially available synthesizer and this unit show that it produces DNA of similar quality.