TY  - JOUR
A1  - Livesay, Eric A.
A1  - Liu, Ying-Horng
A1  - Luebke, Kevin J.
A1  - Irick, Joel
A1  - Belosludtsev, Yuri
A1  - Rayner, Simon
A1  - Balog, Robert
A1  - Johnston, Stephen Albert
T1  - A Scalable High-Throughput Chemical Synthesizer
Y1  - 2002/12/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1950 
EP  - 1960 
DO  - 10.1101/gr.359002 
VL  - 12 
IS  - 12 
UR  - http://genome.cshlp.org/content/12/12/1950.abstract 
N2  - A machine that employs a novel reagent delivery technique for biomolecular synthesis has been developed. This machine separates the addressing of individual synthesis sites from the actual process of reagent delivery by using masks placed over the sites. Because of this separation, this machine is both cost-effective and scalable, and thus the time required to synthesize 384 or 1536 unique biomolecules is very nearly the same. Importantly, the mask design allows scaling of the number of synthesis sites without the addition of new valving. Physical and biological comparisons between DNA made on a commercially available synthesizer and this unit show that it produces DNA of similar quality. 
ER  -