@article{Lundén01122002,
author = {Lundén, Anne and Marklund, Stefan and Gustafsson, Victoria and Andersson, Leif}, 
title = {A Nonsense Mutation in the FMO3 Gene Underlies Fishy Off-Flavor in Cow's Milk},
volume = {12}, 
number = {12}, 
pages = {1885-1888}, 
year = {2002}, 
doi = {10.1101/gr.240202}, 
abstract ={Fish-odor syndrome or Trimethylaminuria (OMIM #602079) in humans is an inborn error of metabolism associated with a characteristic fishy body odor due to elevated levels of trimethylamine (TMA) in body fluids. It is caused by loss-of-function mutations in FMO3encoding flavin-containing mono-oxygenase 3. A fishy off-flavor is occasionally observed in cow's milk and it has been established recently that this phenotype is due to elevated TMA levels. Here, we report that fishy off-flavor in cow's milk is caused by a nonsense mutation (R238X) in the bovine FMO3 ortholog. RT–PCR analysis indicated that the mutant transcript is present in a very low amount. The mutation was found to be surprisingly common (q = 0.155) in one breed of cattle.[The sequence data described in this paper have been submitted to GenBank with accession nos.AF488417–AF488422. The following individuals kindly provided reagents, samples, or unpublished information as indicated in the paper: K. Sandberg and I. Hansson.]}, 
URL = {http://genome.cshlp.org/content/12/12/1885.abstract}, 
eprint = {http://genome.cshlp.org/content/12/12/1885.full.pdf+html}, 
journal = {Genome Research} 
}