RT Journal
A1 Geer, Lewis Y.
A1 Domrachev, Michael
A1 Lipman, David J.
A1 Bryant, Stephen H.
T1 CDART: Protein Homology by Domain Architecture
JF Genome Research 
JO Genome Research 
YR 2002 
FD October 01 
VO 12 
IS 10 
SP 1619 
OP 1623 
DO 10.1101/gr.278202 
UL http://genome.cshlp.org/content/12/10/1619.abstract 
AB The Conserved Domain Architecture Retrieval Tool (CDART) performs similarity searches of the NCBI Entrez Protein Database based on domain architecture, defined as the sequential order of conserved domains in proteins. The algorithm finds protein similarities across significant evolutionary distances using sensitive protein domain profiles rather than by direct sequence similarity. Proteins similar to a query protein are grouped and scored by architecture. Relying on domain profiles allows CDART to be fast, and, because it relies on annotated functional domains, informative. Domain profiles are derived from several collections of domain definitions that include functional annotation. Searches can be further refined by taxonomy and by selecting domains of interest. CDART is available athttp://www.ncbi.nlm.nih.gov/Structure/lexington/lexington.cgi.