RT Journal
A1 Murvai, János
A1 Vlahoviček, Kristian
A1 Szepesvári, Csaba
A1 Pongor, Sándor
T1 Prediction of Protein Functional Domains from Sequences Using Artificial Neural Networks
JF Genome Research 
JO Genome Research 
YR 2001 
FD August 01 
VO 11 
IS 8 
SP 1410 
OP 1417 
DO 10.1101/gr.168701 
UL http://genome.cshlp.org/content/11/8/1410.abstract 
AB An artificial neural network (ANN) solution is described for the recognition of domains in protein sequences. A query sequence is first compared to a reference database of domain sequences by use ofBLAST and the output data, encoded in the form of six parameters, are forwarded to feed-forward artificial neural networks with six input and six hidden units with sigmoidal transfer function. The recognition is based on the distribution of BLASTscores precomputed for the known domain groups in a database versus database comparison. Applications to the prediction of function are discussed.