TY  - JOUR
A1  - Louis, Alexandra
A1  - Ollivier, Emmanuelle
A1  - Aude, Jean-Christophe
A1  - Risler, Jean-Loup
T1  - Massive Sequence Comparisons as a Help in Annotating Genomic Sequences
Y1  - 2001/07/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1296 
EP  - 1303 
DO  - 10.1101/gr.177601 
VL  - 11 
IS  - 7 
UR  - http://genome.cshlp.org/content/11/7/1296.abstract 
N2  - An all-by-all comparison of all the publicly available protein sequences from plants has been performed, followed by a clusterization process. Within each of the 1064 resulting clusters—containing sequences that are orthologous as well as paralogous—the sequences have been submitted to a pyramidal classification and their domains delineated by an automated procedure à la PRODOM. This process provides a means for easily checking for any apparent inconsistency in a cluster, for example, whether one sequence is shorter or longer than the others, one domain is missing, etc. In such cases, the alignment of the DNA sequence of the gene with that of a close homologous protein often reveals (in 10% of the clusters) probable sequencing errors (leading to frameshifts) or probable wrong intron/exon predictions. The composition of the clusters, their pyramidal classifications, and domain decomposition, as well as our comments when appropriate, are available fromhttp://chlora.infobiogen.fr:1234/PHYTOPROT. 
ER  -