RT Journal
A1 Gentles, Andrew J.
A1 Karlin, Samuel
T1 Genome-Scale Compositional Comparisons in Eukaryotes
JF Genome Research 
JO Genome Research 
YR 2001 
FD April 01 
VO 11 
IS 4 
SP 540 
OP 546 
DO 10.1101/gr.163101 
UL http://genome.cshlp.org/content/11/4/540.abstract 
AB We examined dinucleotide relative abundances and their biases in recent sequences of eukaryotic genomes and chromosomes, including human chromosomes 21 and 22, Saccharomyces cerevisiae, Arabidopsis thaliana, and Drosophila melanogaster. We found that dinucleotide relative abundances are remarkably constant across human chromosomes and within the DNA of a particular species. The dinucleotide biases differ between species, providing a genome signature that is characteristic of the bulk properties of an organism's DNA. We detail the relations between species genome signatures and suggest possible mechanisms for their origin and maintenance.