TY - JOUR A1 - Giacalone, Joseph A1 - Delobette, Stephanie A1 - Gibaja, Veronica A1 - Ni, Lei A1 - Skiadas, Yiannis A1 - Qi, Rong A1 - Edington, Joanne A1 - Lai, Zhongwu A1 - Gebauer, Damara A1 - Zhao, Hongjuan A1 - Anantharaman, Thomas A1 - Mishra, Bhubaneswar A1 - Brown, Laura G. A1 - Saxena, Richa A1 - Page, David C. A1 - Schwartz, David C. T1 - Optical Mapping of BAC Clones from the Human Y Chromosome DAZ Locus Y1 - 2000/09/01 JF - Genome Research JO - Genome Research SP - 1421 EP - 1429 DO - 10.1101/gr.112100 VL - 10 IS - 9 UR - http://genome.cshlp.org/content/10/9/1421.abstract N2 - The accurate mapping of clones derived from genomic regions containing complex arrangements of repeated elements presents special problems for DNA sequencers. Recent advances in the automation of optical mapping have enabled us to map a set of 16 BAC clones derived from the DAZ locus of the human Y chromosome long arm, a locus in which the entire DAZ gene as well as subsections within the gene copies have been duplicated. High-resolution optical mapping employing seven enzymes places these clones into two contigs representing four distinct copies of the DAZ gene and highlights a number of differences between individual copies of DAZ. ER -